Job Description

Vertex Pharmaceuticals has an exciting opportunity for a Senior Scientist to join the In-vitro Pharmacology/Electrophysiology group within the Pharmacology Department. We are seeking a motivated, creative, and innovative scientist with a deep understanding of ion channel physiology and pharmacology. A successful candidate will have broad, hands-on experience using a range of in vitro cellular assays. Preference will be given to candidates with extensive experience with patch clamp electrophysiology, MEA, Ca2+-imaging etc. working with primary cells, including human cells. Experience with data analytics and computational modeling & simulation is highly valued. A successful candidate will demonstrate a strong desire to collaborate within a multidisciplinary drug discovery team.

Key Duties and Responsibilities:

• Develop, validate and execute in-vitro assays, including electrophysiology assays, to support drug discovery projects.
• Analyze and interpret complex and multidimensional data and effectively document and communicate results.
• Provide novel insight through data analytics and computational modeling & simulation.
• Work effectively in a multi-disciplinary team environment and have excellent organizational and communication skills.

Knowledge and Skills:

• Extensive knowledge of ion channel physiology and pharmacology and applications to drug discovery.
• Experience with single channel recording and multiple patch clamp configurations (inside-out, cell-attached, etc).
• Demonstrated experience with MEA.
• Ability to analyze complex datasets using MATLAB, Python, etc.
• Background in Neuroscience or Pain and familiarity with drug discovery.
• Ability to navigate and thrive in a fast-paced, highly matrixed work environment.
• Strong desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families, and society.
• Demonstrates ability to solve complex problems to attain crucial Project goals
• Highly effective verbal and written communication skills and attention to detail in preparing business critical documents (e.g. experimental records, SOPs, and study reports).

Education and Experience:

• Degree in Physiology, Pharmacology, or related field
• PhD and 3+ years, or Master's and 5+ years, or Bachelor's and 8+ years.
• In depth experience in the design, execution, and interpretation of manual and/or automated patch-clamp electrophysiology studies.
• Experience with computational modeling & simulation of ion channel behavior and drug combination pharmacology.

Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com