Job Summary:

The Janetzko Laboratory is seeking a postdoctoral fellow to join our efforts to study mechanisms of G protein-coupled receptor (GPCR) signaling, trafficking and regulation. Some of the most exciting questions in the field today involve understanding the spatiotemporal regulation of signaling and our lab will investigate this directly by understanding how local environment and post-translational modifications impact GPCR function as well as how GPCRs are moved from one location to another. We are especially interested in studying GPCRs involved in cellular metabolism and neuromodulation. We are also interested in understanding how transducer dynamics are coupled to ligand binding and how this controls signaling. The ideal candidate will be enthusiastic about joining a brand-new research laboratory that will provide them with an excellent training opportunity towards an independent career in science, either in academics or industry. Our philosophy is to match the right technique to the problem at hand, meaning we employ a diverse set of chemical, cell biological and biophysical approaches in our research. Some of these include crystallography/cryo-EM, cell-based assays, single-molecule fluorescence and structural mass spectrometry, to name a few. Depending on your interests and the directions your project goes you may use several different approaches during your time in the lab.

The Janetzko lab also has one of the only custom-built 4-camera TIRF microscopes in the country to enable our single-molecule work. This instrument will allow us to investigate protein and complex dynamics with unparalleled detail. We will use this, together with innovative optical imaging modalities to study complex assembly and dynamics in native and reconstituted systems to better understand how these systems function in response to drugs and in the context of disease.

Key Responsibilities:

• Pursue research goals established by the Program Director (Dr. John Janetzko).
• Lead primary data collection and maintain accurate and up-to-date records of data
• Analyze data, prepare and present research findings in journal papers and conferences.
• Train, supervise, and provide guidance to student workers, graduate students, professional research assistants, or other personnel as assigned by the Program Director.
• Contribute to and lead grant writing activities.

Work Location:

Onsite - this role is expected to work onsite and is located in Aurora, CO.

Why Join Us:

Why join the Janetzko lab?

A post-doctoral fellowship is an important launching pad for a Ph.D. scientist.

As a fellow, you will be working closely with Prof. Janetzko and will play an important role in shaping the directions of our lab. As such, I expect:

You will be a good role model for more junior lab members (PRAs, graduate students, undergrads etc.) and are willing to take on mentoring responsibilities as they arise.

You are genuinely excited to learn new approaches and to be a steward of learning for more junior lab members.

You are collegial and collaborative. The problems we’re interested in solving require interdisciplinary approaches where multiple experts must work together in pursuit of a common goal. We believe strongly in team science.

You are able to design, execute and interpret experiments [largely] independently. That said, we are a team, and I am available to help with any steps along this process as needed.

You are organized and a clear and effective communicator.

While funding for this position is secured (>=3 years), I expect you to apply for funding opportunities that you’re eligible for as this is an excellent training opportunity.

In exchange, I will:

Provide you with a vibrant and dynamic learning environment.

Support your learning of new techniques by working directly with you or through directly working with our amazing collaborators.

Provide you with a safe and inclusive work environment where your perspectives are valued.

Work with you on manuscript writing and involve you in grant writing to further hone your skills.

Be a support system for your professional advancement and work with you to achieve your career goals, whatever they may be.

Why come to BMG?

Our department conducts research across a wide biological scale for fundamental scientific understanding with applications to many disease contexts. The overarching goal is to reach a level of molecular insight that helps develop therapeutic approaches for the treatment of disease. In BMG, your peers and colleagues will have diverse backgrounds and skill sets which can provide you with new insights and perspectives into your work. They also include experts in structural biology (cryo-EM, NMR, crystallography), mass spectrometry, enzymology and cell biology.

Beyond BMG, the greater CU community has a wealth of opportunities to work with collaborators and experts in different fields. Our lab will work with colleagues in Pharmacy, Pharmacology, Cell Biology, Chemistry and Chemical Engineering and you will be able to benefit from this extended network of interactions.

The University of Colorado offers a comprehensive benefits package that includes health insurance, life insurance, retirement plans, tuition benefits, ECO pass, paid time off – vacation, sick, and holidays and more. To see what benefits are available, please visit:

Diversity and Equity:

The University of Colorado Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. We encourage applications from women, ethnic minorities, persons with disabilities, persons within the LGBTQ+ community and all veterans. The University of Colorado is committed to diversity and equality in education and employment.

Qualifications:

Minimum Qualifications:
Applicants must meet minimum qualifications at the time of hire.

• PhD in chemistry, biochemistry, biology, or a related field.

Preferred Qualifications:

• Candidate must have previous experience with protein expression and purification, ideally from mammalian cells.
• Previous experience with structural biology approaches (ideally cryo-EM) are strongly preferred.
• Previous experience with single-molecule fluorescence spectroscopy is a plus, but not required.
• Previous training in chemistry (bioconjugation, peptide chemistry, etc) is a plus.
• Skills in scientific programming (e.g. Python, R, Matlab) are a major plus.

Knowledge, Skills and Abilities:

• Proficient knowledge of laboratory techniques including safety procedures and techniques.
• Ability to communicate effectively, both in writing and orally.
• Ability to interpret and master complex research protocol information.

How to Apply:

For full consideration, please submit the following document(s):

Applications are accepted electronically ONLY at www.cu.edu/cu-careers.

Questions should be directed to: Anthony Davis, Anthony.j.davis@cuanschutz.edu

Screening of Applications Begins:

Immediately and continues until position is filled. For best consideration, apply by August 30, 2024.

Anticipated Pay Range:

The starting salary range (or hiring range) for this position has been established as HIRING RANGE:

$61,008 - $74,088 (current NIH ranges)

We offer a competitive salary that is negotiable and will generally follow the NIH scale. For exceptional candidates, we are open to discussing additional compensation to ensure the best fit for both parties. Additionally, we provide comprehensive relocation assistance if needed, to help make your transition as smooth as possible.

The above salary range (or hiring range) represents the University’s good faith and reasonable estimate of the range of possible compensation at the time of posting. This position is not eligible for overtime compensation unless it is non-exempt.

Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave, health plans and retirement contributions that add to your bottom line.

Total Compensation Calculator:

ADA Statement:

The University will provide reasonable accommodations to applicants with disabilities throughout the employment application process. To request an accommodation pursuant to the Americans with Disabilities Act, please contact the Human Resources ADA Coordinator at hr.adacoordinator@ucdenver.edu.

Background Check Statement:

The University of Colorado Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees.

Vaccination Statement:

CU Anschutz strongly encourages vaccination against the COVID-19 virus and other vaccine preventable diseases. If you work, visit, or volunteer in healthcare facilities or clinics operated by our affiliated hospital or clinical partners or by CU Anschutz, you will be required to comply with the vaccination and medical surveillance policies of the facilities or clinics where you work, visit, or volunteer, respectively. In addition, if you work in certain research areas or perform certain safety sensitive job duties, you must enroll in the occupational health medical surveillance program.